Long-Term In Vivo Oxygen Sensors for Peripheral Artery Disease Monitoring

Adv Exp Med Biol. 2018;1072:351-356. doi: 10.1007/978-3-319-91287-5_56.


Tracking of tissue oxygenation around chronic foot wounds may help direct therapy decisions in patients with peripheral artery disease (PAD). Novel sensing technology to enable such monitoring was tested over 9 months in a Sinclair mini-pig model. No adverse events were observed over the entire study period. Systemic and acute hypoxia challenges were detected during each measurement period by the microsensors. The median time to locate the sensor signal was 13 s. Lumee Oxygen microsensors appear safe for long-term repeated oxygen measurements over 9 months.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Biosensing Techniques* / instrumentation
  • Biosensing Techniques* / methods
  • Hydrogel, Polyethylene Glycol Dimethacrylate
  • Oxygen / analysis*
  • Peripheral Arterial Disease*
  • Swine
  • Swine, Miniature


  • Hydrogel, Polyethylene Glycol Dimethacrylate
  • Oxygen