Protein expressions of AIB1, p53 and Bcl-2 in epithelial ovarian cancer and their correlations with the clinical pathological features and prognosis

Eur Rev Med Pharmacol Sci. 2018 Aug;22(16):5134-5139. doi: 10.26355/eurrev_201808_15708.


Objective: To investigate the protein expressions of steroid receptor coactivator amplified in breast cancer 1 (AIB1), apoptosis-related protein p53 and B-cell lymphoma-2 (Bcl-2) in epithelial ovarian cancer; to analyze the correlations among the expressions of these three proteins; to explore their correlations with the clinical pathological features and prognosis.

Materials and methods: Immunohistochemistry streptavidin-peroxidase (IHC-SP) method was performed to detect the positive protein expressions of AIB1, Bcl-2, and p53 in the pathological sections of normal ovarian tissues, benign ovarian epithelial tumor, and epithelial ovarian cancer, thereby analyzing the protein expression rates of these genes in different pathological stages, lymphatic metastasis and postoperative recurrent ovarian cancer, and carrying out the correlation analysis of these three proteins.

Results: Positive protein expressions of AIB1, Bcl-2, and p53 were identified in the epithelial ovarian cancer tissues, and with an increase in the tumor staging of ovarian cancer, we found that the positive protein expression rate was gradually augmented. Particularly in ovarian cancer with lymphatic metastasis and postoperative recurrence, the positive expression rate was almost 100%. The protein expression of AIB1 was positively correlated with those of the p53 and Bcl-2.

Conclusions: We showed that positive expressions of AIB1, Bcl-2, and p53 in ovarian cancer are closely correlated with the pathological staging, metastasis, and recurrence, and the positive protein expression suggests a poor prognosis.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Carcinoma, Ovarian Epithelial / diagnosis
  • Carcinoma, Ovarian Epithelial / genetics
  • Carcinoma, Ovarian Epithelial / metabolism*
  • Female
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Middle Aged
  • Neoplasm Recurrence, Local / diagnosis
  • Neoplasm Recurrence, Local / genetics
  • Neoplasm Recurrence, Local / metabolism*
  • Nuclear Receptor Coactivator 3 / biosynthesis*
  • Nuclear Receptor Coactivator 3 / genetics
  • Ovarian Neoplasms / diagnosis
  • Ovarian Neoplasms / genetics
  • Ovarian Neoplasms / metabolism*
  • Prognosis
  • Proto-Oncogene Proteins c-bcl-2 / biosynthesis*
  • Proto-Oncogene Proteins c-bcl-2 / genetics
  • Tumor Suppressor Protein p53 / biosynthesis*
  • Tumor Suppressor Protein p53 / genetics
  • Young Adult


  • Proto-Oncogene Proteins c-bcl-2
  • Tumor Suppressor Protein p53
  • NCOA3 protein, human
  • Nuclear Receptor Coactivator 3