Chemokine Receptor 4 Expression in Primary Sjögren's Syndrome

Clin Nucl Med. 2018 Nov;43(11):835-836. doi: 10.1097/RLU.0000000000002258.


Ga-pentixafor is a novel radioligand of C-X-C motif chemokine receptor 4. A 55-year-old woman with a history of primary Sjögren's syndrome underwent Ga-pentixafor PET/CT for staging of lymphoma originating from mucosa-associated lymphoid tissue. Whereas no lymphoma manifestation could be detected, imaging revealed bilateral intense radiotracer uptake in both parotid and submandibular salivary glands, consistent with inflammatory cell infiltration.

Publication types

  • Case Reports

MeSH terms

  • Coordination Complexes*
  • Female
  • Humans
  • Middle Aged
  • Peptides, Cyclic*
  • Positron Emission Tomography Computed Tomography*
  • Radiopharmaceuticals*
  • Sjogren's Syndrome / diagnostic imaging*


  • 68Ga-pentixafor
  • Coordination Complexes
  • Peptides, Cyclic
  • Radiopharmaceuticals