Purpose: To investigate the spectral domain optical coherence tomography findings before and after dialysis in patients with diabetic end-stage renal disease undergoing dialysis for the first time.
Methods: A retrospective medical review of patients with diabetic end-stage renal disease who recently started dialysis was conducted. Spectral domain optical coherence tomography findings before and after initiation of dialysis were analyzed. Systemic blood pressure, body weight, estimated glomerular filtration rate, and serum levels of blood urea nitrogen, creatinine (Cr), albumin, hemoglobin (Hb), and total CO2 were measured before and 1 month after starting dialysis. The correlations between the changes in these variables and the degree of decrease of the central subfield thickness after initiation of dialysis were analyzed.
Results: A total 26 eyes from 15 patients were included. Among them, 14 started hemodialysis, and 1 started peritoneal dialysis. After initiation of dialysis, the incidence of any macular edema significantly decreased from 69.2% (18/26) to 26.9% (7/26) (P = 0.001). The central subfield thickness (317.92 ± 91.41 vs. 287.77 ± 57.55 μm, P = 0.006) and subfoveal choroidal thickness (313.31 ± 85.89 vs. 288.81 ± 92.02; P = 0.024) also significantly decreased. Improvement in blood urea nitrogen, Cr, Hb, and total CO2 levels in serum and estimated glomerular filtration rate was observed. A significant positive correlation between the amount of central subfield thickness decrease and the decrease in serum blood urea nitrogen was found (Pearson correlation coefficient: 0.481, P = 0.013).
Conclusion: Macular edema and central subfield thickness significantly decreased after initiation of dialysis in patients with diabetic chronic renal failure without any ocular treatment. This may be related to the improvement in uremia and volume overload after the initiation of dialysis.
Spectral-domain Optical Coherence Tomography Retinal and Choroidal Thickness Metric Repeatability in Age-related Macular DegenerationD Hanumunthadu et al. Am J Ophthalmol 166, 154-161. PMID 27066726.This study suggests that a change of greater than 31 μm in Spectralis SDOCT-derived retinal thickness measurement of the central macular subfield and 35 μm in subfoveal c …
Effect of Hemodialysis (HD) on Intraocular Pressure, Ocular Surface, and Macular Change in Patients With Chronic Renal Failure. Effect of Hemodialysis on the Ophthalmologic FindingsJW Jung et al. Graefes Arch Clin Exp Ophthalmol 251 (1), 153-62. PMID 22552572.The changes in the ophthalmologic findings after HD were consistent and significant in all CRF subjects. These changes correlated with the increase in plasma colloid osmo …
CHANGES IN CHOROIDAL THICKNESS IN AND OUTSIDE THE MACULA AFTER HEMODIALYSIS IN PATIENTS WITH END-STAGE RENAL DISEASEIB Chang et al. Retina 37 (5), 896-905. PMID 27557086.Changes in body weight, serum osmolarity, and BP during HD may affect choroidal thickness in and outside the macula.
Renal Function and Choroidal Thickness Using Swept-Source Optical Coherence Tomography in Diabetic PatientsAM Garrido-Hermosilla et al. Int J Ophthalmol 12 (6), 985-989. PMID 31236357.Choroidal thickness can represent an additional tool to help clinicians predicting the renal status in ocular treatment-naïve diabetic patients.
Changes in Retina and Choroid After Haemodialysis Assessed Using Optical Coherence Tomography AngiographyY Zhang et al. Clin Exp Optom 101 (5), 674-679. PMID 29359351.In optical coherence tomography angiography, the retinal thickness became thinner and the vascular density in the outer retina decreased after haemodialysis in patients w …
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Relationship Between Diabetic Macular Edema and Choroidal Layer ThicknessH Endo et al. PLoS One 15 (1), e0226630. PMID 31910216.The total and outer CCT layers of diabetic eyes were significantly thickened in the DME+DT-as compared with the DME-DT+group, suggesting that CCT may be related to the pa …