Longitudinal changes in social cognition in individuals at clinical high risk for psychosis: An outcome based analysis

Schizophr Res. 2019 Feb;204:334-336. doi: 10.1016/j.schres.2018.08.032. Epub 2018 Sep 1.


Social cognition deficits have been observed in individuals at clinical high risk (CHR) for psychosis. Longitudinal change in social cognition were analyzed in CHR individuals from the North American Prodrome Longitudinal Study (NAPLS2) based on outcome at 24 months. Individuals (n = 359) were classified into remission, symptomatic, prodromal progression and transition to psychosis (CHR-T) groups. Social cognition was assessed using theory of mind, emotion perception, and social perception tasks. There were no differences at baseline or 24 months between the groups on social cognition. Non-transition groups improved significantly over time on social cognition, but CHR-T did not show this effect.

Keywords: Clinical high risk; Emotion perception; Psychosis; Social cognition; Social perception; Theory of mind.

Publication types

  • Multicenter Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Disease Progression*
  • Emotions / physiology*
  • Facial Expression
  • Facial Recognition / physiology*
  • Female
  • Humans
  • Longitudinal Studies
  • Male
  • Prodromal Symptoms*
  • Psychotic Disorders / physiopathology*
  • Remission Induction
  • Risk
  • Social Perception*
  • Theory of Mind / physiology*
  • Young Adult