Simultaneous high-resolution cardiac T 1 mapping and cine imaging using model-based iterative image reconstruction

Magn Reson Med. 2019 Feb;81(2):1080-1091. doi: 10.1002/mrm.27474. Epub 2018 Sep 5.

Abstract

Purpose: To provide high-resolution cardiac T1 mapping of various cardiac phases and cine imaging within a single breath-hold using continuous golden ratio-based radial acquisition and model-based iterative image reconstruction.

Methods: Data acquisition was performed continuously using golden ratio-based radial sampling and multiple inversion pulses were applied independent of the heart rate. Native T1 maps of diastole and systole were reconstructed with in-plane resolution of 1.3 × 1.3 mm2 using model-based iterative image reconstruction. Cine images with 30 cardiac phases were reconstructed from the same data using kt-SENSE. The method was evaluated in a commercially available T1 phantom and 10 healthy subjects. In vivo T1 assessment was carried out segment-wise.

Results: Evaluation in the phantom demonstrated accurate T1 times (R2 > 0.99) and insensitivity to the heart rate. In vivo T1 values did not differ between systole and diastole, and T1 times assessed by the proposed approach were longer than measured with a modified Look-Locker inversion recovery (MOLLI) sequence, except for lateral segments. Cine images had a consistent dark-blood contrast and functional assessment was in agreement with assessment based on Cartesian cine scans (difference in ejection fraction: 0.26 ± 2.65%, P = 0.65).

Conclusion: The proposed approach provides native T1 maps of diastole and systole with high spatial resolution and cine images simultaneously within 16 s, which could strongly improve the scan efficiency.

Keywords: T1 mapping; cine imaging; model-based reconstruction; multiparametric acquisition; myocardial tissue characterization.

MeSH terms

  • Adult
  • Algorithms
  • Breath Holding
  • Diastole
  • Electrocardiography
  • Female
  • Healthy Volunteers
  • Heart / diagnostic imaging
  • Heart Rate*
  • Humans
  • Image Interpretation, Computer-Assisted / methods
  • Image Processing, Computer-Assisted / methods*
  • Magnetic Resonance Imaging, Cine*
  • Male
  • Motion
  • Phantoms, Imaging
  • Reproducibility of Results
  • Systole
  • Young Adult