A Mitochondrial-Derived Peptide Exercises the Nuclear Option

Kailash C Mangalhara; Gerald S Shadel

doi:10.1016/j.cmet.2018.08.017

A Mitochondrial-Derived Peptide Exercises the Nuclear Option

Cell Metab. 2018 Sep 4;28(3):330-331. doi: 10.1016/j.cmet.2018.08.017.

Authors

Kailash C Mangalhara¹, Gerald S Shadel²

Affiliations

¹ Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
² Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: gshadel@salk.edu.

PMID: 30184481
DOI: 10.1016/j.cmet.2018.08.017

Abstract

The vast majority of mitochondrial proteins are encoded by nuclear genes, giving the nucleus ultimate control of mitochondrial biogenesis, dynamics, and function. However, in this issue Kim et al. (2018) demonstrate a reversal of fortune, whereby an mtDNA-encoded peptide, MOTS-c, is targeted to the nucleus to signal changes in gene expression.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Cell Nucleus*
DNA, Mitochondrial
Mitochondria / genetics*
Peptides
Stress, Physiological

Substances

DNA, Mitochondrial
Peptides

Grants and funding

R33 ES025636/ES/NIEHS NIH HHS/United States