Abstract
Transmission of the bovine papillomavirus-1 (BPV-1) genome through the mouse germ line results in the heritable formation of fibropapillomas of the skin, a tissue-specific phenotype analogous to that observed in natural BPV-1 infection of cattle. Oncogenesis is slow, with tumours first arising at 8-9 months of age, usually in areas prone to wounding. Extrachromosomal BPV-1 DNA is detected in all tumours, whereas normal tissues show only integrated DNA.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Age Factors
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Animals
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Bovine papillomavirus 1 / genetics
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Bovine papillomavirus 1 / pathogenicity*
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DNA, Neoplasm / analysis
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DNA, Recombinant*
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DNA, Viral / genetics*
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Extrachromosomal Inheritance
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Female
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Fibroma / etiology*
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Fibroma / genetics
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Male
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Mice
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Mice, Inbred C57BL
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Mice, Inbred DBA
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Neoplasms, Multiple Primary / etiology
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Neoplasms, Multiple Primary / genetics
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Papilloma / etiology*
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Papilloma / genetics
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Papillomaviridae / pathogenicity*
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Skin Neoplasms / etiology*
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Skin Neoplasms / genetics
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Skin Neoplasms / pathology
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Transfection
Substances
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DNA, Neoplasm
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DNA, Recombinant
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DNA, Viral