Bovine papillomavirus genome elicits skin tumours in transgenic mice

Nature. 1986 Aug 14-20;322(6080):609-12. doi: 10.1038/322609a0.

Abstract

Transmission of the bovine papillomavirus-1 (BPV-1) genome through the mouse germ line results in the heritable formation of fibropapillomas of the skin, a tissue-specific phenotype analogous to that observed in natural BPV-1 infection of cattle. Oncogenesis is slow, with tumours first arising at 8-9 months of age, usually in areas prone to wounding. Extrachromosomal BPV-1 DNA is detected in all tumours, whereas normal tissues show only integrated DNA.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Animals
  • Bovine papillomavirus 1 / genetics
  • Bovine papillomavirus 1 / pathogenicity*
  • DNA, Neoplasm / analysis
  • DNA, Recombinant*
  • DNA, Viral / genetics*
  • Extrachromosomal Inheritance
  • Female
  • Fibroma / etiology*
  • Fibroma / genetics
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Inbred DBA
  • Neoplasms, Multiple Primary / etiology
  • Neoplasms, Multiple Primary / genetics
  • Papilloma / etiology*
  • Papilloma / genetics
  • Papillomaviridae / pathogenicity*
  • Skin Neoplasms / etiology*
  • Skin Neoplasms / genetics
  • Skin Neoplasms / pathology
  • Transfection

Substances

  • DNA, Neoplasm
  • DNA, Recombinant
  • DNA, Viral