The Bone Marrow Microenvironment in Waldenström Macroglobulinemia

Shahrzad Jalali; Stephen M Ansell

doi:10.1016/j.hoc.2018.05.005

The Bone Marrow Microenvironment in Waldenström Macroglobulinemia

Hematol Oncol Clin North Am. 2018 Oct;32(5):777-786. doi: 10.1016/j.hoc.2018.05.005. Epub 2018 Jul 25.

Authors

Shahrzad Jalali¹, Stephen M Ansell²

Affiliations

¹ Division of Hematology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA.
² Division of Hematology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA. Electronic address: ansell.stephen@mayo.edu.

PMID: 30190017
DOI: 10.1016/j.hoc.2018.05.005

Abstract

Waldenström macroglobulinemia (WM) is an indolent B-cell lymphoma defined predominantly by infiltration of lymphoplasmacytic cells into the bone marrow (BM) and increased production of monoclonal immunoglobulin M (IgM) by lymphoplasmacytic cells, and the secretion of IgM is enhanced by cytokines in the bone marrow microenvironment. This article highlights the available data regarding the interaction of WM cells with both the cellular and noncellular compartments of the BM microenvironment and discusses how the BM promotes malignant cell growth and increases IgM production in this disease.

Keywords: Angiogenesis; Bone marrow niche; Cytokines; Homing; Immune cells; Microenvironment; Waldenström macroglobulinemia.

Publication types

Review

MeSH terms

Bone Marrow* / metabolism
Bone Marrow* / pathology
Humans
Immunoglobulin M / genetics
Immunoglobulin M / metabolism
Neoplasm Proteins / genetics
Neoplasm Proteins / metabolism
Plasma Cells* / metabolism
Plasma Cells* / pathology
Tumor Microenvironment*
Waldenstrom Macroglobulinemia* / genetics
Waldenstrom Macroglobulinemia* / metabolism
Waldenstrom Macroglobulinemia* / pathology

Substances

Immunoglobulin M
Neoplasm Proteins