Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1986 Jul;30(1):147-51.
doi: 10.1128/AAC.30.1.147.

Inhibition of electron transfer and uncoupling effects by emodin and emodinanthrone in Escherichia coli

Inhibition of electron transfer and uncoupling effects by emodin and emodinanthrone in Escherichia coli

T Ubbink-Kok et al. Antimicrob Agents Chemother. 1986 Jul.

Abstract

The anthraquinones emodin (1,3,delta-trihydroxy-6-methylanthraquinone) and emodinanthrone (1,3,8-trihydroxy-6-methylanthrone) inhibited respiration-driven solute transport at micromolar concentrations in membrane vesicles of Escherichia coli. This inhibition was enhanced by Ca ions. The inhibitory action on solute transport is caused by inhibition of electron flow in the respiratory chain, most likely at the level between ubiquinone and cytochrome b, and by dissipation of the proton motive force. The uncoupling action was confirmed by studies on the proton motive force in beef heart cytochrome oxidase proteoliposomes. These two effects on energy transduction in cytoplasmic membranes explain the antibiotic properties of emodin and emodinanthrone.

PubMed Disclaimer

Similar articles

Cited by

References

    1. J Biol Chem. 1971 Sep 10;246(17):5523-31 - PubMed
    1. J Biol Chem. 1961 Jun;236:1680-8 - PubMed
    1. J Biol Chem. 1972 Feb 25;247(4):1338-9 - PubMed
    1. J Agric Food Chem. 1972 Mar-Apr;20(2):431-4 - PubMed
    1. Eur J Biochem. 1973 Apr 2;34(1):58-67 - PubMed

LinkOut - more resources