Complement 5a Receptor Polymorphisms Are Associated With Panton-Valentine Leukocidin-positive Staphylococcus aureus Colonization in African Pygmies

Clin Infect Dis. 2019 Feb 15;68(5):854-856. doi: 10.1093/cid/ciy666.

Abstract

Panton-Valentine leukocidin (PVL) is common in African Staphylococcus aureus and can be associated with skin and soft tissue infection. PVL-positive S. aureus colonization is associated with a variant of complement receptor 5a, the cellular target of the lukS PVL subunit.

Keywords: Staphylococcus aureus; Panton-Valentine leukocidin; complement C5a; polymorphism; receptor.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • African Continental Ancestry Group / genetics*
  • Bacterial Toxins / genetics
  • Bacterial Toxins / metabolism*
  • Carrier State
  • Exotoxins / genetics
  • Exotoxins / metabolism*
  • Female
  • Humans
  • Leukocidins / genetics
  • Leukocidins / metabolism*
  • Male
  • Polymorphism, Single Nucleotide*
  • Receptor, Anaphylatoxin C5a / genetics*
  • Staphylococcus aureus / genetics*
  • Staphylococcus aureus / physiology*

Substances

  • Bacterial Toxins
  • Exotoxins
  • Leukocidins
  • Panton-Valentine leukocidin
  • Receptor, Anaphylatoxin C5a