Insecticide Exposure and Development of Nonalcoholic Fatty Liver Disease

J Agric Food Chem. 2018 Oct 3;66(39):10132-10138. doi: 10.1021/acs.jafc.8b03177. Epub 2018 Sep 20.

Abstract

Nonalcoholic fatty liver disease (NAFLD) is the prevalent liver disease resulting from metabolic disorder, which is highly associated with obesity and type 2 diabetes. Emerging evidence has shown that insecticide exposure disrupts lipid and glucose metabolism and results in obesity and type 2 diabetes. However, the potential impact of insecticide exposure on the liver functions related to NAFLD development is largely unknown. Thus, this perspective focused on the current knowledge of the effect of insecticides on the liver functions, particularly lipid and glucose metabolism, as well as other liver functions to correlate insecticide exposure and the development of NAFLD.

Keywords: NAFLD; glucose metabolism; insecticides; lipid metabolism; oxidative stress.

Publication types

  • Review

MeSH terms

  • Animals
  • Glucose / metabolism
  • Humans
  • Insecticides / toxicity*
  • Lipid Metabolism / drug effects
  • Liver / drug effects
  • Liver / metabolism
  • Non-alcoholic Fatty Liver Disease / etiology*
  • Non-alcoholic Fatty Liver Disease / metabolism

Substances

  • Insecticides
  • Glucose