Pour Some Sugar on TDP(-43)

Mol Cell. 2018 Sep 6;71(5):649-651. doi: 10.1016/j.molcel.2018.08.032.


In this issue of Molecular Cell, McGurk et al. (2018) identify how poly(ADP-ribose) binding tunes the phase behavior of the ALS disease protein TDP-43, uncovering the molecular events underlying its aggregation in disease and illuminating a novel therapeutic target.

Publication types

  • Comment

MeSH terms

  • Amyotrophic Lateral Sclerosis*
  • DNA-Binding Proteins
  • Humans
  • Poly Adenosine Diphosphate Ribose*
  • Sugars


  • DNA-Binding Proteins
  • Sugars
  • TARDBP protein, human
  • Poly Adenosine Diphosphate Ribose