Freeing Yeast from Alcohol Addiction (Just) to Make (It) Fat Instead

Cell. 2018 Sep 6;174(6):1342-1344. doi: 10.1016/j.cell.2018.08.024.


Synthetically re-designing eukaryotic metabolism has proven immensely challenging, raising the question of whether evolution has metabolically hardwired eukaryotic cells. Yu et al. now report that, through orchestrating multiple genetic changes and laboratory evolution, Saccharomyces metabolism can be reprogrammed from its evolutionary objective of producing ethanol to produce large amounts of free fatty acids.

Publication types

  • Comment

MeSH terms

  • Alcoholism*
  • Ethanol
  • Fermentation
  • Humans
  • Lipogenesis
  • Saccharomyces cerevisiae


  • Ethanol