Under a progressive growth of acute hypoxia the effect of high systemic levels of proinflammatory cytokine interleukin-1 Р (IL-1Р) were studied the reactions of the cardiorespiratory system of anesthetized Wistar rats. The results suggest a negative effect of IL-1 Р on the control mechanisms the respiratory and cardiovascular system, which was reflected in the reduction of resistance to acute hypoxia and the ability to spontaneous autoresuscitation after apnea in posthypoxic period, as well as in the development of circulatory collapse. It is assumed that the basis of the resistance mechanisms of the body to reduce the hypoxic exposure is multifactorial effects of increased levels of IL-1 Р, activation of HIF-1 a and NO production in the operation of the systems responsible for maintaining oxygen homeostasis.