Commentary on the Impact of Obesity on PediatricDiabetes

Clin Ther. 2018 Oct;40(10):1631-1637. doi: 10.1016/j.clinthera.2018.08.006. Epub 2018 Sep 5.

Abstract

While conventionally most children diagnosed with diabetes are thought to have type 1 diabetes mellitus (T1DM), with the increased prevalence of obesity, more are being affected by type 2 (T2) DM. Obesity leads to increased insulin resistance, which over time can lead to progressive β-cell failure and ultimately T2DM. However, patients developing T1DM may also be obese, making both the proper classification and management of diabetes in children more challenging. In this commentary, the authors discuss the impact ofobesity on the presentation of pediatric diabetes, how to differentiate between T1DM and T2DM, and the proper management of both diseases.

Keywords: diabetes mellitus; insulin resistance; obesity; pediatrics; type 1; type 2.

MeSH terms

  • Child
  • Diabetes Mellitus, Type 1 / epidemiology*
  • Diabetes Mellitus, Type 2 / epidemiology*
  • Humans
  • Insulin Resistance
  • Pediatric Obesity / complications*
  • Prevalence