Adipose tissue and the physiologic underpinnings of metabolic disease

Surg Obes Relat Dis. 2018 Nov;14(11):1755-1763. doi: 10.1016/j.soard.2018.07.032. Epub 2018 Aug 7.


Adipose tissue dysfunction underlies the pathogenesis of metabolic disease. The metrics used to quantify adiposity and its association with metabolic disease, including body mass index, have limitations with important clinical implications. An understanding of the molecular and cellular mechanisms by which adipose tissue regulates systemic metabolism and contributes to metabolic disease will lead to next-generation adipose tissue-based therapy.

Keywords: Adipose tissue; Body mass index; Cell stress responses; Metabolic disease; Obesity.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Adipose Tissue* / metabolism
  • Adipose Tissue* / physiology
  • Adipose Tissue* / physiopathology
  • Body Mass Index
  • Cell- and Tissue-Based Therapy
  • Humans
  • Metabolic Diseases* / metabolism
  • Metabolic Diseases* / physiopathology
  • Metabolic Diseases* / therapy
  • Obesity