Prevalence and incidence of clinically diagnosed Alzheimer's disease dementia from 1994 to 2012 in a population study

Alzheimers Dement. 2019 Jan;15(1):1-7. doi: 10.1016/j.jalz.2018.07.216. Epub 2018 Sep 7.

Abstract

Introduction: The trends in prevalence and incidence of Alzheimer's disease (AD) dementia remain uncertain.

Methods: A sample of 2794 participants with a clinical diagnosis for AD dementia were included.

Results: The 2010 census standardized prevalence of AD dementia was 14.5% (95% CI = 13.7-15.3), and annual incidence was 2.3% (1.7-2.9). Both prevalence and incidence showed substantial variation over time, but no secular trends. The prevalence of AD dementia did not change significantly from 14.6% (95% CI = 13.0, 16.2) in 1994-1997 to 14.7% (95% CI = 13.2, 16.2) in 2010-2012 (P = .84). The annual incidence of AD dementia was 2.8% (95% CI = 2.2, 3.2) in 1998-2000 and 2.2% (95% CI = 1.6, 2.8) in 2004-2006 (P = .20) and remained steady in 2010-2012. The prevalence and incidence among African Americans were approximately twice than those among European Americans.

Conclusions: The prevalence and incidence of AD dementia showed substantial variation between 1994 and 2012, but no secular trend.

Keywords: Dementia trends; Epidemiological study; Incidence; Prevalence.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • African Americans / statistics & numerical data*
  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / diagnosis
  • Alzheimer Disease / epidemiology*
  • Female
  • Humans
  • Incidence
  • Male
  • Prevalence
  • Prospective Studies
  • Risk Factors
  • United States / epidemiology
  • Whites / statistics & numerical data*