Functionalized glycolipids for potential bioconjugation of vesicles

Mojtaba Tabandeh; Ean Wai Goh; Abbas Abdulameer Salman; Thorsten Heidelberg; Rusnah Syahila Duali Hussen

doi:10.1016/j.carres.2018.08.016

Functionalized glycolipids for potential bioconjugation of vesicles

Carbohydr Res. 2018 Nov:469:14-22. doi: 10.1016/j.carres.2018.08.016. Epub 2018 Aug 30.

Authors

Mojtaba Tabandeh¹, Ean Wai Goh¹, Abbas Abdulameer Salman², Thorsten Heidelberg³, Rusnah Syahila Duali Hussen¹

Affiliations

¹ Chemistry Department, Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia.
² Chemistry Department, Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia; College of Pathological Analysis Technology, Al-Bayan University, Bhagdad, Iraq.
³ Chemistry Department, Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia. Electronic address: heidelberg@um.edu.my.

PMID: 30196011
DOI: 10.1016/j.carres.2018.08.016

Abstract

Two azide-terminated oligoethylene oxide spacered glycolipids have been synthesized, and their assembly behavior has been studied in comparison to the corresponding base surfactants. The results suggest potential of the Guerbet lactoside-based compound for targeted drug delivery, while a coiling of the ethylene oxide linker disfavors the application of the glucoside.

Keywords: Biantennary glycolipid; CLICK chemistry coupling; Ethylene oxide spacer; Surfactant assembly; Targeted drug delivery; Vesicle bioconjugation.

MeSH terms

Glycolipids / chemistry*
Hydrogen Bonding
Lipid Bilayers / chemistry*
Models, Molecular
Molecular Conformation
Surface Properties

Substances

Glycolipids
Lipid Bilayers