Nonreplicative functions of the origin recognition complex

Varvara V Popova; Alexander V Brechalov; Sofia G Georgieva; Daria V Kopytova

doi:10.1080/19491034.2018.1516484

Nonreplicative functions of the origin recognition complex

Nucleus. 2018;9(1):460-473. doi: 10.1080/19491034.2018.1516484.

Authors

Varvara V Popova¹, Alexander V Brechalov¹, Sofia G Georgieva¹, Daria V Kopytova¹

Affiliation

¹ a Department of Transcription Regulation and Chromatin Dynamics , Institute of Gene Biology, Russian Academy of Sciences , Moscow , Russia.

Abstract

Origin recognition complex (ORC), a heteromeric six-subunit complex, is the central component of the eukaryotic pre-replication complex. Recent data from yeast, frogs, flies and mammals present compelling evidence that ORC and its individual subunits have nonreplicative functions as well. The majority of these functions, such as heterochromatin formation, chromosome condensation, and segregation are dependent on ORC-DNA interactions. Furthermore, ORC is involved in the control of cell division via its participation in centrosome duplication and cytokinesis. Recent findings have also demonstrated a direct interaction between ORC and mRNPs and highlighted an essential role of ORC in mRNA nuclear export. Along with the growth of evolutionary complexity of organisms, ORC complex functions become more elaborate and new functions of the ORC sub-complexes and individual subunits have emerged.

Keywords: HP1; ORC; Origin recognition complex; SIR; TREX-2; centrosomes; cohesin; mRNA export; mRNP; sister chromatids.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Humans
Origin Recognition Complex / metabolism*

Substances

Origin Recognition Complex

Grants and funding

This work was supported by the Russian Academy of Sciences [The program of the Presidium of the Russian Academy of Sciences ‘Molecular and Cellular Biology’]; Russian Science Foundation [14–14–01059].