Novel gene activated in rat insulinomas

Diabetes. 1986 Oct;35(10):1178-80. doi: 10.2337/diab.35.10.1178.


Insulinomas can be induced in experimental animals by the combined administration of diabetogenic agents with polyadenosine diphosphate (polyADP)-ribose synthetase inhibitors. A complementary DNA (cDNA) library that was constructed from streptozocin-nicotinamide-induced rat insulinomas has been found to contain a novel gene encoding a basic protein of 145 amino acids. The gene was expressed in alloxan-nicotinamide-induced insulinomas as well as in streptozocin-nicotinamide-induced insulinomas but not in normal pancreatic islets or in regenerating islets. This indicates that the activation of the gene designated rig, i.e., rat insulinoma gene, may be a general feature of pancreatic beta-cell transformation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenoma, Islet Cell / genetics*
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cloning, Molecular
  • DNA / metabolism
  • Insulinoma / genetics*
  • Male
  • Oncogenes*
  • Pancreatic Neoplasms / genetics*
  • Rats
  • Rats, Inbred Strains


  • DNA

Associated data

  • GENBANK/M19393