Preparation of [99mTc(DMPE)2Cl2]+ for myocardial imaging by using Fe-(DMPE) complexes

Int J Rad Appl Instrum A. 1986;37(3):197-200. doi: 10.1016/0883-2889(86)90170-x.

Abstract

The preparation of [99mTc(1,2-bis(dimethylphosphino)ethane)2Cl2]+ ([99mTc(DMPE)2Cl2]+) for imaging the myocardium is investigated. Starting from Fe(III)- or Fe(II)-DMPE and 99mTcO4- different preparation variants are compared. In these reactions either ascorbic acid or DTPA serves as an agent for complexing iron. A simple procedure using lyophilized initial components is represented. Its application yields [99mTc(DMPE)2Cl2]+ with a radiochemical purity of more than 95%. Organ distribution studies performed in rats emphasize the high myocardial accumulation of this preparation.

MeSH terms

  • Animals
  • Heart / diagnostic imaging
  • Hydrogen-Ion Concentration
  • Iron*
  • Isotope Labeling*
  • Organometallic Compounds*
  • Organotechnetium Compounds*
  • Phosphines* / metabolism
  • Radionuclide Imaging
  • Rats
  • Rats, Inbred Strains
  • Technetium* / metabolism
  • Tissue Distribution

Substances

  • Organometallic Compounds
  • Organotechnetium Compounds
  • Phosphines
  • Technetium
  • technetium Tc 99m bis(1,2-dimethylphosphino)ethane
  • iron bis(1,2-dimethylphosphino)ethane complex
  • Iron