Effects of Cefotaxime and Cefodizime on Human Granulocyte Functions in Vitro

J Antimicrob Chemother. 1986 Aug;18(2):233-7. doi: 10.1093/jac/18.2.233.

Abstract

In vitro, cefotaxime and cefodizime enhanced significantly the bactericidal activity of human neutrophils against Staphylococcus aureus P 209 A, but not phagocytosis. The increase was about 150% for cefotaxime and 400% for cefodizime at concentrations as low as 1 mg/l. Furthermore, by two different techniques (NBT and cytochrome C reduction tests) cefotaxime but not cefodizime significantly enhanced superoxide anion production by zymosan-stimulated neutrophils. Other neutrophil functions (chemotaxis and myeloperoxidase-mediated iodination of proteins) were not significantly altered by either antibiotic, even at concentrations as high as 1000 mg/l.

Publication types

  • Comparative Study

MeSH terms

  • Blood Bactericidal Activity / drug effects
  • Cefotaxime / analogs & derivatives*
  • Cefotaxime / pharmacology*
  • Chemotaxis, Leukocyte / drug effects
  • Humans
  • In Vitro Techniques
  • Neutrophils / drug effects*
  • Neutrophils / metabolism
  • Peroxidase / metabolism
  • Phagocytosis / drug effects
  • Superoxides / metabolism

Substances

  • Superoxides
  • Peroxidase
  • Cefotaxime
  • cefodizime