Connectome to behaviour: modelling Caenorhabditis elegans at cellular resolution

Philos Trans R Soc Lond B Biol Sci. 2018 Sep 10;373(1758):20170366. doi: 10.1098/rstb.2017.0366.


It has been 30 years since the 'mind of the worm' was published in Philosophical Transactions B (White et al 1986 Phil. Trans. R. Soc. Lond. B314, 1-340). Predicting Caenorhabditis elegans' behaviour from its wiring diagram has been an enduring challenge since then. This special theme issue of Philosophical Transactions B combines research from neuroscientists, physicists, mathematicians and engineers to discuss advances in neural activity imaging, behaviour quantification and multiscale simulations, and how they are bringing the goal of whole-animal modelling at cellular resolution within reach.This article is part of a discussion meeting issue 'Connectome to behaviour: modelling C. elegans at cellular resolution'.

Keywords: Caenorhabditis elegans; behaviour; connectome; nervous system; open data; simulation.

Publication types

  • Introductory Journal Article
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Caenorhabditis elegans / physiology*
  • Connectome / methods*
  • Models, Neurological
  • Nervous System Physiological Phenomena*