Association of GDF-5 rs143383 polymorphism with radiographic defined knee osteoarthritis: A systematic review and meta-analysis

J Orthop. 2018 Aug 24;15(4):945-951. doi: 10.1016/j.jor.2018.08.033. eCollection 2018 Dec.

Abstract

Objective: To assess the association of GDF-5 rs143383 polymorphism with radiographic defined knee osteoarthritis (OA), a systematic review and meta-analysis was conducted.

Methods: A total of 17 relevant case-control studies with 7424 cases and 11,310 controls was collected from several electronic databases up to June 2018.

Results: The pooled results showed that GDF-5 rs143383 polymorphism was significantly associated with radiographic defined knee OA in overall and stratified analysis by ethnicity, source of controls and genotyping techniques.

Conclusions: The GDF-5 rs143383 polymorphism might be used as a relevant risk estimate for radiographic defined Knee OA.

Keywords: GDF-5 gene; Knee; Meta-analysis; Osteoarthritis; Radiographic.