Optical coherence tomography angiography (OCTA) comprises different OCT-based technologies developed for non-invasive assessment and measurement of optic nerve head and retinal perfusion. Currently the most clinically established approach is based on the split spectrum amplitude decorrelation algorithm, which detects moving red blood cells and eliminates all other information. The two main clinical fields in which OCTA offers clinically useful information are investigation of the macular retina (e.g. in macular degeneration and diabetic macular disease) and glaucoma. For glaucoma, the optic nerve head and the peripapillary retinal perfusion in the retinal nerve fiber layer, and the superficial perifoveal macular vasculature are the areas of interest. This review provides a comprehensive summary of the most important current and potential future applications of OCTA in glaucoma, but it does not address the nonglaucomatous optic nerve head or peripapillary and macular diseases.
Keywords: Glaucoma; OCTA; macula; optical coherence tomography angiography; perfusion; peripapillary retinal nerve fiber layer.