Structural analysis reveals the formation and role of RNA G-quadruplex structures in human mature microRNAs

Chem Commun (Camb). 2018 Sep 25;54(77):10878-10881. doi: 10.1039/c8cc04635b.


Here we identify hundreds of RNA G-quadruplex (rG4) candidates in microRNAs (miRNAs), characterize the miRNA structure and miRNA-mRNA interactions on several mammalian-conserved miRNAs, and reveal the formation of rG4s in miRNAs. Notably, we study the effect of these rG4s in cells and uncover the role of rG4s in miRNA-mediated post-transcriptional regulation.

MeSH terms

  • G-Quadruplexes*
  • HEK293 Cells
  • Humans
  • MicroRNAs / chemistry*
  • MicroRNAs / metabolism


  • MicroRNAs