Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors

Nature. 1986 Sep 18-24;323(6085):226-32. doi: 10.1038/323226a0.

Abstract

The primary structure of the receptor for platelet-derived growth factor (PDGF), determined by means of cloning a cDNA that encodes the murine pre-PDGF receptor, is closely related to that of the v-kit oncogene product and the receptor for macrophage colony stimulating factor (CSF-1). Common structural features include the presence of long sequences that interrupt the tyrosine-specific protein kinase domains of each molecule. The PDGF and CSF-1 receptors also share a characteristic distribution of extracellular cysteine residues. Ubiquitin is covalently bound to the purified PDGF receptor, the human gene for which is on chromosome 5.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Chromosomes, Human, Pair 5
  • Cloning, Molecular
  • DNA / genetics
  • Humans
  • Mice
  • Multigene Family
  • Platelet-Derived Growth Factor*
  • Protein-Tyrosine Kinases / genetics*
  • Receptors, Cell Surface* / genetics
  • Receptors, Platelet-Derived Growth Factor

Substances

  • Platelet-Derived Growth Factor
  • Receptors, Cell Surface
  • DNA
  • Protein-Tyrosine Kinases
  • Receptors, Platelet-Derived Growth Factor

Associated data

  • GENBANK/X04367