A Dilution Model for Embryonic Scaling

Dev Cell. 2018 Sep 10;46(5):529-530. doi: 10.1016/j.devcel.2018.08.020.


A recent study in Nature Cell Biology (Almuedo-Castillo et al., 2018) describes a mechanism for tissue scaling in zebrafish embryos. The authors show that a fixed relative amount of the diffusible Nodal inhibitor Lefty produces an extended gradient in larger embryos, ensuring proportionally scaled germ layers, irrespective of embryo size.

Publication types

  • Comment

MeSH terms

  • Animals
  • Gene Expression Regulation, Developmental*
  • Germ Layers
  • Left-Right Determination Factors*
  • Nodal Protein
  • Transforming Growth Factor beta / genetics
  • Zebrafish
  • Zebrafish Proteins / genetics


  • Left-Right Determination Factors
  • Nodal Protein
  • Transforming Growth Factor beta
  • Zebrafish Proteins