Location, Location, Location: Mutant NPM1c Cytoplasmic Localization Is Required to Maintain Stem Cell Genes in AML

Abstract

In this issue of Cancer Cell, Brunetti and colleagues elucidate the role of mutant NPM1c and its cytoplasmic mislocalization in acute myeloid leukemia. They demonstrate how mutant-specific degradation or relocalization leads to a loss of the stem cell signature characteristic of these leukemias and induces their differentiation.