Antiviral Activities of Oleanolic Acid and Its Analogues

Molecules. 2018 Sep 9;23(9):2300. doi: 10.3390/molecules23092300.


Viral diseases, such as human immune deficiency virus (HIV), influenza, hepatitis, and herpes, are the leading causes of human death in the world. The shortage of effective vaccines or therapeutics for the prevention and treatment of the numerous viral infections, and the great increase in the number of new drug-resistant viruses, indicate that there is a great need for the development of novel and potent antiviral drugs. Natural products are one of the most valuable sources for drug discovery. Most natural triterpenoids, such as oleanolic acid (OA), possess notable antiviral activity. Therefore, it is important to validate how plant isolates, such as OA and its analogues, can improve and produce potent drugs for the treatment of viral disease. This article reports a review of the analogues of oleanolic acid and their selected pathogenic antiviral activities, which include HIV, the influenza virus, hepatitis B and C viruses, and herpes viruses.

Keywords: HBV/HCV; HIV; influenza virus; medicinal plant; natural product; triterpenoids.

Publication types

  • Review

MeSH terms

  • Antiviral Agents / chemistry
  • Antiviral Agents / pharmacology*
  • Drug Resistance, Multiple, Viral / drug effects
  • Drug Synergism
  • Humans
  • Oleanolic Acid / analogs & derivatives*
  • Pentacyclic Triterpenes / chemistry
  • Pentacyclic Triterpenes / pharmacology*
  • Plant Extracts / pharmacology
  • Plants, Medicinal / chemistry


  • Antiviral Agents
  • Pentacyclic Triterpenes
  • Plant Extracts
  • Oleanolic Acid