Interface fluid syndrome secondary to endothelial failure due to toxic anterior segment syndrome after cataract surgery

Eur J Ophthalmol. 2019 May;29(3):NP1-NP4. doi: 10.1177/1120672118800241. Epub 2018 Sep 11.


Purpose: To present a case of previous laser in situ keratomileusis with interface fluid syndrome secondary to toxic anterior segment syndrome following cataract surgery.

Case report: A 52-year-old woman, complaining blurred vision in her right eye for 18 months after cataract surgery, was referred to our clinic. She was diagnosed with toxic anterior segment syndrome, postoperatively, which resolved in 3 days. She had a history of laser in situ keratomileusis surgery 15 years ago. Slit-lamp examination of the right eye showed corneal haze, limited to laser in situ keratomileusis flap. The patient was diagnosed with interface fluid syndrome secondary to endothelial decompensation due to toxic anterior segment syndrome. Descemet's membrane endothelial keratoplasy was performed along with full thickness fenestrations in the laser in situ keratomileusis flap to the right eye of the patient. The fluid was resolved in 1 week and visual acuity was improved rapidly.

Conclusion: This case shows the importance of considering the diagnosis and determining the specific etiology of interface fluid syndrome, even years after the laser in situ keratomileusis surgery, when endothelial cell function has been compromised with any factor, such as intraocular surgery and its complications.

Keywords: Descemet’s membrane endothelial keratoplasy; Interface fluid syndrome; laser in situ keratomileusis complications; toxic anterior segment syndrome.

Publication types

  • Case Reports

MeSH terms

  • Anterior Eye Segment / pathology*
  • Anterior Eye Segment / surgery
  • Body Fluids
  • Cataract Extraction / adverse effects*
  • Corneal Edema / diagnosis
  • Corneal Edema / etiology*
  • Corneal Edema / surgery
  • Corneal Topography
  • Descemet Stripping Endothelial Keratoplasty
  • Endothelium, Corneal / pathology*
  • Endothelium, Corneal / surgery
  • Eye Diseases / diagnosis
  • Eye Diseases / etiology*
  • Eye Diseases / surgery
  • Female
  • Humans
  • Middle Aged
  • Slit Lamp Microscopy
  • Tomography, Optical Coherence
  • Visual Acuity / physiology