Bronchiectasis: Treatment decisions for pulmonary exacerbations and their prevention

Respirology. 2018 Nov;23(11):1006-1022. doi: 10.1111/resp.13398. Epub 2018 Sep 11.


Interest in bronchiectasis has increased over the past two decades, as shown by the establishment of disease-specific registries in several countries, the publication of management guidelines and a growing number of clinical trials to address evidence gaps for treatment decisions. This review considers the evidence for defining and treating pulmonary exacerbations, the approaches for eradication of newly identified airway pathogens and the methods to prevent exacerbations through long-term treatments from a pragmatic practice-based perspective. Areas for future studies are also explored. Watch the video abstract.

Keywords: Pseudomonas aeruginosa; bacterial infection; bronchiectasis; eradication; pulmonary exacerbations.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Anti-Bacterial Agents* / classification
  • Anti-Bacterial Agents* / pharmacology
  • Bacterial Infections* / microbiology
  • Bacterial Infections* / physiopathology
  • Bacterial Infections* / prevention & control
  • Bronchiectasis* / diagnosis
  • Bronchiectasis* / microbiology
  • Bronchiectasis* / physiopathology
  • Bronchiectasis* / therapy
  • Clinical Decision-Making
  • Clinical Protocols
  • Disease Progression
  • Humans
  • Symptom Flare Up


  • Anti-Bacterial Agents