Endoscopic Resection Followed by Proton Therapy With Pencil Beam Scanning for Skull Base Tumors

Laryngoscope. 2019 Jun;129(6):1313-1317. doi: 10.1002/lary.27512. Epub 2018 Sep 12.


For patients who require postoperative radiotherapy after endoscopic resection of skull base tumors, proton therapy with pencil beam scanning (PBS) may allow sparing of normal tissue compared to intensity-modulated photon radiation (IMRT). We compared PBS and IMRT radiation plans in the preoperative and postoperative settings for two patients with advanced skull base tumors following endoscopic resection. The benefits of PBS over IMRT appear greater in the postoperative setting following endoscopic resection with improved sparing of critical organs at risk. The multidisciplinary approach of endoscopic resection followed by PBS represents a treatment paradigm with potential for improvements in toxicity reduction. Laryngoscope, 129:1313-1317, 2019.

Keywords: Skull base; endoscopic surgery; head and neck cancer; proton therapy.

Publication types

  • Case Reports
  • Research Support, N.I.H., Extramural

MeSH terms

  • Aged, 80 and over
  • Endoscopy / methods*
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Neurosurgical Procedures / methods*
  • Proton Therapy / methods*
  • Radiotherapy Dosage
  • Radiotherapy, Intensity-Modulated / methods*
  • Skull Base Neoplasms / diagnosis
  • Skull Base Neoplasms / therapy*
  • Young Adult