Enhancement of methotrexate cytotoxicity by uracil analogues that inhibit deoxyuridine triphosphate nucleotidohydrolase (dUTPase) activity

Adv Exp Med Biol. 1986:195 Pt B:97-104. doi: 10.1007/978-1-4684-1248-2_16.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cattle
  • Cell Cycle / drug effects
  • Cell Survival / drug effects*
  • Cells, Cultured
  • DNA / biosynthesis
  • DNA / metabolism
  • DNA Glycosylases*
  • Humans
  • In Vitro Techniques
  • Methotrexate / toxicity*
  • Mice
  • N-Glycosyl Hydrolases / metabolism
  • Pyrophosphatases / antagonists & inhibitors*
  • Thymine Nucleotides / metabolism
  • Uracil / analogs & derivatives*
  • Uracil / pharmacology
  • Uracil-DNA Glycosidase

Substances

  • Thymine Nucleotides
  • Uracil
  • DNA
  • DNA Glycosylases
  • N-Glycosyl Hydrolases
  • Uracil-DNA Glycosidase
  • Pyrophosphatases
  • dUTP pyrophosphatase
  • thymidine 5'-triphosphate
  • Methotrexate