Sensitization to Fungi in Atopic Dermatitis Patients 14 Year and Older - Association with Other Atopic Diseases and Parameters

Jarmila Celakovská; Bukac Josef; Karel Ettler; Jaroslava Vaneckova; Kvetuse Ettlerova; Krejsek Jan

doi:10.4103/ijd.IJD_493_17

Sensitization to Fungi in Atopic Dermatitis Patients 14 Year and Older - Association with Other Atopic Diseases and Parameters

Indian J Dermatol. 2018 Sep-Oct;63(5):391-398. doi: 10.4103/ijd.IJD_493_17.

Authors

Jarmila Celakovská¹, Bukac Josef², Karel Ettler¹, Jaroslava Vaneckova¹, Kvetuse Ettlerova³, Krejsek Jan⁴

Affiliations

¹ Department of Dermatology and Venereology, Faculty Hospital and Medical Faculty of Charles University, Hradec Králové, Czech Republic.
² Department of Medical Biophysic, Medical Faculty of Charles University, Hradec Králové, Czech Republic.
³ Department of Allergy and Clinical Immunology, Outpatient Clinic, Hradec Králové, Czech Republic.
⁴ Department of Clinical Immunology and Allergy, Faculty Hospital and Medical Faculty of Charles University, Hradec Králové, Czech Republic.

Abstract

Background: Fungi as a source of allergen are still largely neglected in basic research as well as in clinical practice. This study aimed to highlight the impact of fungal allergens in a group of patients suffering from atopic dermatitis (AD).

Aims and objectives: The evaluation of the sensitization to fungi in AD patients aged 14 year and older and the evaluation of the relation of fungal sensitization to the occurrence of other atopic diseases and parameters.

Materials and methods: All patients satisfying inclusion criteria attending our hospital between 2008 and 2017 were included in the study. The complete dermatological and allergological examinations were performed in all included patients including examination of specific immunoglobulin E, skin prick test to mixture of fungi and inhalant allergens, evaluation of asthma bronchiale, rhinitis, onset of AD, family history about atopy, duration of eczematous lesions, severity of AD. Pairs of these categories were entered in the contingency tables and the Chi-square test for relationship of these variables was performed with the level of significance set below 5%.

Results: Three hundred and thirty-one patients were included in the study; the average age was 26.8 years. The sensitization to fungi was recorded in 100 patients (30%). In these patients, the occurrence of asthma bronchiale, rhinitis, family history about atopy, sensitization to grass and trees was significantly higher than in patients without sensitization to fungi. We did not find any significant relation between the sensitization to fungi and the severity of AD, no relation was also found between the sensitization to fungi and sensitization to mites, animal dander, bird feather, and dust.

Conclusion: The occurrence of asthma bronchiale, rhinitis, family history about atopy, sensitization to grass and trees was significantly higher in AD patients with sensitization to fungi. No relation was found between the severity of AD and the sensitization to fungi.

Keywords: Asthma bronchiale; atopic dermatitis; persistent eczematous lesions; rhinitis; sensitization to fungi.