Delayed Post-hypoxic Leukoencephalopathy (DPHL)-An Uncommon Variant of Hypoxic Brain Damage in Adults

Front Neurol. 2018 Aug 27;9:708. doi: 10.3389/fneur.2018.00708. eCollection 2018.


Delayed post-hypoxic leukoencephalopathy (DPHL) is an uncommon, potentially under-recognized, cause of hypoxia induced white matter injury. It characteristically follows a biphasic course: After an initial phase of altered neurologic status a recovery occurs which is then followed by a recurring phase of neurologic deterioration, typically 2-4 weeks after the initial event. At this time white matter changes can be identified on MRI, which are the hallmark of DPHL. The characteristics and the typical MR-imaging signs of DPHL are discussed in this case report.

Keywords: CT; DPHL; MRI; delayed post-hypoxic leukoencephalopathy; hypoxic brain damage in adults; ischemia; neuroradiology; white matter.

Publication types

  • Case Reports