Over the past 30 years, the incidence in of hepatocellular carcinoma (HCC) in the United States has tripled, largely due to untreated chronic Hepatitis C virus, alcoholic hepatitis, and non-alcoholic steatohepatitis (NASH). Additionally, the incidence of HCC among South Texas Hispanics is higher than elsewhere in the United States. The median age of HCC is 62 years in United States and 67 years in South Texas, with over 30% being 70 years of age or older. However, there is limited data on how to treat older adults with advanced HCC. In this review, we will discuss treatment options for older adults with advanced HCC, further emphasizing the need for prospective studies in this population.
Keywords: hepatocellular carcinoma; older adult; sorafenib; targeted therapy; treatment options.
Conflict of interest statement
Conflict of Interest: No conflicts declared.
A comparison of survival and pathologic features of non-alcoholic steatohepatitis and hepatitis C virus patients with hepatocellular carcinoma.World J Gastroenterol. 2012 Aug 21;18(31):4145-9. doi: 10.3748/wjg.v18.i31.4145. World J Gastroenterol. 2012. PMID: 22919246 Free PMC article.
Hepatocellular carcinoma in non-alcoholic steatohepatitis: Growing evidence of an epidemic?Hepatol Res. 2012 Jan;42(1):1-14. doi: 10.1111/j.1872-034X.2011.00872.x. Epub 2011 Sep 15. Hepatol Res. 2012. PMID: 21917086
Outcomes of curative treatment for hepatocellular cancer in nonalcoholic steatohepatitis versus hepatitis C and alcoholic liver disease.Hepatology. 2012 Jun;55(6):1809-19. doi: 10.1002/hep.25536. Epub 2012 Apr 23. Hepatology. 2012. PMID: 22183968
Hepatocellular carcinoma in non-alcoholic steatohepatitis: Current knowledge and implications for management.World J Hepatol. 2017 Apr 18;9(11):533-543. doi: 10.4254/wjh.v9.i11.533. World J Hepatol. 2017. PMID: 28469809 Free PMC article. Review.
Clinical features of hepatocellular carcinoma associated with nonalcoholic fatty liver disease: a review of human studies.Clin J Gastroenterol. 2015 Feb;8(1):1-9. doi: 10.1007/s12328-014-0548-5. Epub 2015 Jan 10. Clin J Gastroenterol. 2015. PMID: 25575848 Review.
Cited by 1 article
Hepatocellular carcinoma in older adults: A comprehensive review by Young International Society of Geriatric Oncology.J Geriatr Oncol. 2020 May;11(4):557-565. doi: 10.1016/j.jgo.2019.10.007. Epub 2019 Nov 6. J Geriatr Oncol. 2020. PMID: 31704038 Review.