Recurrent schilder's disease

Mult Scler Relat Disord. 2018 Nov:26:8-10. doi: 10.1016/j.msard.2018.09.001. Epub 2018 Sep 5.


Schilder's disease is a rare and aggressive central nervous system demyelinating disorder that is typically monophasic and steroid responsive. Here, we present an unusual case of a teenager with Schilder's disease who was treated with corticosteroids and had a clinical and radiographic recurrence nearly one year after the initial presentation.

Keywords: Myelinoclastic diffuse sclerosis; Rituxumab; Schilder's disease; Tumefactive multiple sclerosis.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Diffuse Cerebral Sclerosis of Schilder* / diagnostic imaging
  • Diffuse Cerebral Sclerosis of Schilder* / drug therapy
  • Diffuse Cerebral Sclerosis of Schilder* / physiopathology
  • Glucocorticoids / administration & dosage
  • Glucocorticoids / pharmacology*
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Recurrence
  • Rituximab / administration & dosage
  • Rituximab / pharmacology*


  • Glucocorticoids
  • Rituximab