The Significance of Chondroitin Sulfate Proteoglycan 4 (CSPG4) in Human Gliomas

Int J Mol Sci. 2018 Sep 12;19(9):2724. doi: 10.3390/ijms19092724.


Neuron glial antigen 2 (NG2) is a chondroitin sulphate proteoglycan 4 (CSPG4) that occurs in developing and adult central nervous systems (CNSs) as a marker of oligodendrocyte precursor cells (OPCs) together with platelet-derived growth factor receptor α (PDGFRα). It behaves variably in different pathological conditions, and is possibly involved in the origin and progression of human gliomas. In the latter, NG2/CSPG4 induces cell proliferation and migration, is highly expressed in pericytes, and plays a role in neoangiogenesis. NG2/CSPG4 expression has been demonstrated in oligodendrogliomas, astrocytomas, and glioblastomas (GB), and it correlates with malignancy. In rat tumors transplacentally induced by N-ethyl-N-nitrosourea (ENU), NG2/CSPG4 expression correlates with PDGFRα, Olig2, Sox10, and Nkx2.2, and with new vessel formation. In this review, we attempt to summarize the normal and pathogenic functions of NG2/CSPG4, as well as its potential as a therapeutic target.

Keywords: CNS; NG2/CSPG4; development; gliomagenesis; vessels.

Publication types

  • Review

MeSH terms

  • Adult
  • Animals
  • Central Nervous System / metabolism
  • Central Nervous System / pathology
  • Chondroitin Sulfate Proteoglycans / metabolism*
  • Glioblastoma / metabolism*
  • Glioblastoma / pathology
  • Glioma / metabolism*
  • Glioma / pathology
  • Homeobox Protein Nkx-2.2
  • Homeodomain Proteins
  • Humans
  • Membrane Proteins / metabolism*
  • Nuclear Proteins
  • Rats
  • Transcription Factors


  • CSPG4 protein, human
  • Chondroitin Sulfate Proteoglycans
  • Homeobox Protein Nkx-2.2
  • Homeodomain Proteins
  • Membrane Proteins
  • NKX2-2 protein, human
  • Nkx2-2 protein, rat
  • Nuclear Proteins
  • Transcription Factors