Alternative splicing of RNAs transcribed from the human abl gene and from the bcr-abl fused gene

Cell. 1986 Oct 24;47(2):277-84. doi: 10.1016/0092-8674(86)90450-2.

Abstract

The primary structure of normal abl protein was determined by sequencing the coding region of its cDNA. abl contains two alternative 5' exons spliced to a common set of 3' exons to yield the two major abl RNA transcripts. These transcripts initiate in different promoter regions and give rise to proteins that vary in their N-termini. In the human cell line K562, abl is translocated from chromosome 9 to within the bcr gene on chromosome 22. Within the fused bcr-abl gene, abl exon II alternatively splices to two adjacent bcr exons. This phenomenon is seen in many patients with chronic myeloid leukemia.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Abelson murine leukemia virus / genetics*
  • Amino Acid Sequence
  • Chromosomes, Human, Pair 22
  • Chromosomes, Human, Pair 9
  • DNA / genetics
  • Exons
  • Gene Expression Regulation
  • Humans
  • Leukemia Virus, Murine / genetics*
  • Leukemia, Myeloid / genetics
  • Philadelphia Chromosome
  • Promoter Regions, Genetic
  • Proto-Oncogene Proteins / genetics*
  • Proto-Oncogenes*
  • RNA Splicing
  • Translocation, Genetic*

Substances

  • Proto-Oncogene Proteins
  • DNA

Associated data

  • GENBANK/M14752
  • GENBANK/M14753
  • GENBANK/M14754
  • GENBANK/M14755
  • GENBANK/M15055