Stem Cells in Dermatology and Anti-aging Care of the Skin

Facial Plast Surg Clin North Am. 2018 Nov;26(4):425-437. doi: 10.1016/j.fsc.2018.06.004. Epub 2018 Aug 16.


Multipotent stem cells have paved the way for new applications and deeper understanding in regenerative medicine and the pathophysiology of aging. During skin aging, cumulative photodamage, exhaustion of endogenous stem cell populations, mechanical stress, and increased fibrosis lead to skin with decreased epidermal thickness and compromised dermal integrity. Specific stem cells in the hair follicle create new keratinocytes after activation by defensin peptides, released by neutrophils during wounding. Studies pertaining to defensin peptides' efficacy on skin aging have been published, highlighting their potential as a new therapy for skin rejuvenation.

Keywords: Anti-aging skin care; Anti-microbial peptide; Defensin; Epidermal thickness; Melanin; Pore reduction; Stem cells; Wrinkles.

Publication types

  • Review

MeSH terms

  • Defensins / metabolism*
  • Epidermal Cells / metabolism
  • Hair Follicle / cytology
  • Humans
  • Receptors, G-Protein-Coupled / metabolism*
  • Rejuvenation
  • Skin Aging*
  • Stem Cells / metabolism*


  • Defensins
  • LGR6 protein, human
  • Receptors, G-Protein-Coupled