Mesothelial Stem Cells and Stromal Vascular Fraction for Skin Rejuvenation

David A Wolf; William Beeson; John D Rachel; Gregory S Keller; C William Hanke; Jill Waibel; Matt Leavitt; Michael Sacopulos

doi:10.1016/j.fsc.2018.06.011

Mesothelial Stem Cells and Stromal Vascular Fraction for Skin Rejuvenation

Facial Plast Surg Clin North Am. 2018 Nov;26(4):513-532. doi: 10.1016/j.fsc.2018.06.011. Epub 2018 Aug 16.

Authors

David A Wolf¹, William Beeson², John D Rachel³, Gregory S Keller⁴, C William Hanke⁵, Jill Waibel⁶, Matt Leavitt⁷, Michael Sacopulos⁸

Affiliations

¹ Johnson Space Center, Houston, TX, USA; EarthTomorrow, Inc, 1714 Neptune Lane, Houston, TX 77062, USA; Purdue University, West Lafayette, IN, USA.
² Facial Plastics, Indianapolis, IN, USA; Department of Dermatology, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Otolaryngology-Head and Neck Surgery, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address: bill@beeson.com.
³ Facial Plastics, Chicago, IL, USA.
⁴ Facial Plastics, Santa Barbara, CA, USA; Facial Plastics, Los Angeles, CA, USA.
⁵ Dermatology, Indianapolis, IN, USA; Laser and Skin Center of Indiana, 13400 North Meridian Street, Suite 290, Carmel, IN 46032, USA; ACGME Micrographic Surgery, Dermatologic Oncology Fellowship Training Program, St. Vincent Hospital, Indianapolis, IN, USA; University of Iowa-Carver College of Medicine, Iowa City, IA, USA; University of Cincinnati College of Medicine, Cincinnati, OH, USA.
⁶ Dermatology, Miami Dermatology and Laser Institute, 7800 Southwest 87th Avenue, Suite B200, Miami, FL 33173, USA; Baptist Hospital of Miami, Miami, FL, USA; Miller School of Medicine, University of Miami, Miami, FL, USA.
⁷ Dermatology, Orlando, FL, USA; Advanced Dermatology and Cosmetic Surgery, The Hair Foundation, 260 Lookout Place Suite 103, Maitland, FL 32751, USA; University of Central Florida, 6850 Lake Nona Boulevard, Orlando, FL 32827, USA; Nova Southeastern University, 4850 Millenium Boulevard, Orlando, FL 32839, USA.
⁸ Medical Risk Management, Medical Risk Institute, 676 Ohio Street, Terre Haute, IN 47807, USA.

PMID: 30213431
DOI: 10.1016/j.fsc.2018.06.011

Abstract

The use of stem cells in regenerative medicine and specifically facial rejuvenation is thought provoking and controversial. Today there is increased emphasis on tissue engineering and regenerative medicine, which translates into a need for a reliable source of stem cells in addition to biomaterial scaffolds and cytokine growth factors. Adipose tissue is currently recognized as an accessible and abundant source for adult stem cells. Cellular therapies and tissue engineering are still in their infancy, and additional basic science and preclinical studies are needed before cosmetic and reconstructive surgical applications can be routinely undertaken and satisfactory levels of patient safety achieved.

Keywords: Adipose-derived stem cells; Growth factors; Mesenchymal stem cells; Regenerative medicine; Stromal vascular fraction (SVF).

Publication types

Review

MeSH terms

Adipose Tissue / cytology*
Adipose Tissue / transplantation
Biomedical Research / legislation & jurisprudence*
Cell Culture Techniques
Cell- and Tissue-Based Therapy
Humans
Induced Pluripotent Stem Cells / metabolism
Induced Pluripotent Stem Cells / transplantation*
Intercellular Signaling Peptides and Proteins
Regeneration
Rejuvenation*
Skin Aging / pathology
Skin Aging / physiology*
Stem Cell Transplantation* / ethics
Stem Cell Transplantation* / legislation & jurisprudence
Wound Healing

Substances

Intercellular Signaling Peptides and Proteins