Mitochondria in Developmental and Adult Neurogenesis

Neurotox Res. 2019 Aug;36(2):257-267. doi: 10.1007/s12640-018-9942-y. Epub 2018 Sep 13.


Generation of new neurons is a tightly regulated process that involves several intrinsic and extrinsic factors. Among them, a metabolic switch from glycolysis to oxidative phosphorylation, together with mitochondrial remodeling, has emerged as crucial actors of neurogenesis. However, although accumulating data raise the importance of mitochondrial morphology and function in neural stem cell proliferation and differentiation during development, information regarding the contribution of mitochondria to adult neurogenesis processes remains limited. In the present review, we discuss recent evidence covering the importance of mitochondrial morphology, function, and energy metabolism in the regulation of neuronal development and adult neurogenesis, and their impact on memory processes.

Keywords: Adult neurogenesis; Development; Mitochondria; Neurons.

Publication types

  • Review

MeSH terms

  • Adult
  • Animals
  • Cell Differentiation / physiology
  • Humans
  • Mitochondria / physiology*
  • Neural Stem Cells / physiology*
  • Neurogenesis / physiology*
  • Neurons / physiology*