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Review
. 2018 Aug;118(2):315-323.
doi: 10.1002/jso.25139. Epub 2018 Sep 14.

Fluorescent-guided Surgery for Sentinel Lymph Node Detection in Gastric Cancer and Carcinoembryonic Antigen Targeted Fluorescent-Guided Surgery in Colorectal and Pancreatic Cancer

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Free PMC article
Review

Fluorescent-guided Surgery for Sentinel Lymph Node Detection in Gastric Cancer and Carcinoembryonic Antigen Targeted Fluorescent-Guided Surgery in Colorectal and Pancreatic Cancer

Floris A Vuijk et al. J Surg Oncol. .
Free PMC article

Abstract

Sentinel lymph node procedures for gastric cancer resections using indocyanine green (ICG) linked to Nanocoll outperformed normal ICG but did not provide information on possible lymph node metastasis. Carcinoembryonic antigen targeted fluorescent imaging using SGM-101 was successful in both pancreatic and colorectal cancer. A large phase III multicentre trial will soon be initiated in colorectal cancer patients.

Keywords: lymphatic metastasis; molecular imaging; pancreatic neoplasm; rectal neoplasm.

Figures

Figure 1
Figure 1
Ex vivo fluorescence imaging of a recurrent rectal tumor using SGM‐101 (injected 4 days before surgery, 10 mg). The remaining fluorescence (arrow) was confirmed tumor‐positive. Color (left column), fluorescence (middle column), and merged (right column) images [Color figure can be viewed at wileyonlinelibrary.com]

Comment in

  • Response to the Letter to the Editor.
    Vuijk FA, Hilling DE, Mieog JSD, Vahrmeijer AL. Vuijk FA, et al. J Surg Oncol. 2019 Mar;119(3):399. doi: 10.1002/jso.25310. Epub 2018 Dec 3. J Surg Oncol. 2019. PMID: 30508288 No abstract available.

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