Recent Developments in Solid-Phase Strategies towards Synthetic, Sequence-Defined Macromolecules

Chem Asian J. 2018 Dec 4;13(23):3611-3622. doi: 10.1002/asia.201801171. Epub 2018 Oct 23.


Sequence-control in synthetic polymers is an important contemporary research area because it provides the opportunity to create completely novel materials for structure-function studies. This is especially relevant for biomimetic polymers, bioactive and information security materials. The level of control is strongly dependent and inherent upon the polymerization technique utilized. Today, the most established method yielding monodispersity and monomer sequence-definition is solid-phase synthesis. This Focus Review highlights recent advances in solid-phase strategies to access synthetic, sequence-defined macromolecules. Alternatives strategies towards sequence-defined macromolecules are also briefly summarized.

Keywords: poly(amidoamines); polymerization; sequence-controlled polymers; sequence-defined macromolecules; solid phase.

Publication types

  • Review