Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 23 (9)

Bioavailability of Tea Catechins and Its Improvement


Bioavailability of Tea Catechins and Its Improvement

Zhuo-Yu Cai et al. Molecules.


Many in vitro studies have shown that tea catechins had vevarious health beneficial effects. However, inconsistent results between in vitro and in vivo studies or between laboratory tests and epidemical studies are observed. Low bioavailability of tea catechins was an important factor leading to these inconsistencies. Research advances in bioavailability studies involving absorption and metabolic biotransformation of tea catechins were reviewed in the present paper. Related techniques for improving their bioavailability such as nanostructure-based drug delivery system, molecular modification, and co-administration of catechins with other bioactives were also discussed.

Keywords: Camellia sinensis; bioavailability; catechins; interaction; nanoparticle.

Conflict of interest statement

The authors declare no conflict of interest.


Figure 1
Figure 1
Schematic diagram of metabolism of green tea catechins [28,32,33,37].
Figure 2
Figure 2
Molecular structures of (−)-epigallocatechin-3-gallate (EGCG) and EGCG-based prodrugs and analogs.

Similar articles

See all similar articles

Cited by 8 articles

See all "Cited by" articles


    1. Nagle D.G., Ferreira D., Zhou Y.D. Epigallocatechin-3-gallate (EGCG): Chemical and biomedical perspectives. Phytochemistry. 2006;67:1849–1855. doi: 10.1016/j.phytochem.2006.06.020. - DOI - PMC - PubMed
    1. Koch W., Kukula-Koch W., Komsta Ł., Marzec Z., Szwerc W., Głowniak K. Green tea quality evaluation based on its catechins and metals composition in combination with chemometric analysis. Molecules. 2018;23:1689 doi: 10.3390/molecules23071689. - DOI - PMC - PubMed
    1. Miyazawa T. Absorption, metabolism and antioxidative effects of tea catechin in humans. Biofactors. 2000;13:55–59. doi: 10.1002/biof.5520130110. - DOI - PubMed
    1. Fu Q.Y., Li Q.S., Lin X.M., Qiao R.Y., Yang R., Li X.M., Dong Z.B., Xiang L.P., Zheng X.Q., Lu J.L., et al. Antidiabetic effects of tea. Molecules. 2017;22:849 doi: 10.3390/molecules22050849. - DOI - PMC - PubMed
    1. Cavet M.E., Harrington K.L., Vollmer T.R., Ward K.W., Zhang J.Z. Anti-inflammatory and anti-oxidative effects of the green tea polyphenol epigallocatechin gallate in human corneal epithelial cells. Mol. Vis. 2011;17:533–542. - PMC - PubMed