NLRP3 inflammasome-dependent pyroptosis is proposed to be involved in the mechanism of age-dependent isoflurane-induced cognitive impairment

J Neuroinflammation. 2018 Sep 14;15(1):266. doi: 10.1186/s12974-018-1299-x.

Abstract

Wang Z et al. recently published a paper, titled "Critical role of NLRP3-caspase-1 pathway in age-dependent isoflurane-induced microglial inflammatory response and cognitive impairment". The finding in this paper is consistent with our previous study on NLRP3-caspase-1 pathway. Here, we propose that NLRP3 inflammasome-dependent pyroptosis may be involved in the mechanism of age-dependent isoflurane-induced cognitive impairment and discuss that inhibiting NLRP3 inflammasome activation with a novel inhibitor MCC950 may ameliorate age-dependent isoflurane-induced neuro-inflammation.

Keywords: Cognition; Isoflurane; MCC950; NLRP3; Pyroptosis.

Publication types

  • Letter

MeSH terms

  • Aging / physiology*
  • Anesthetics, Inhalation / toxicity*
  • Cognition Disorders* / chemically induced
  • Cognition Disorders* / complications
  • Cognition Disorders* / metabolism
  • Cytokines / metabolism
  • Humans
  • Isoflurane / toxicity*
  • NLR Family, Pyrin Domain-Containing 3 Protein / metabolism*

Substances

  • Anesthetics, Inhalation
  • Cytokines
  • NLR Family, Pyrin Domain-Containing 3 Protein
  • Isoflurane