Appendectomy and Risk of Parkinson's Disease in Two Large Prospective Cohorts of Men and Women

Mov Disord. 2018 Sep;33(9):1492-1496. doi: 10.1002/mds.109. Epub 2018 Sep 14.


Background: Prior work on appendectomy and PD has produced mixed results. In this study we examined whether history of self-reported appendectomy was related to risk of incident Parkinson's disease in the Nurses' Health Study and the Health Professionals Follow-up Study.

Methods: We used the Cox proportional hazards model to estimate the hazard ratio of Parkinson's disease associated with self-report of appendectomy in men and women. Among women, we estimated the hazard ratio of Parkinson's disease associated with appendectomy for appendicitis and incidental appendectomy.

Results: In pooled analyses, self-report of any appendectomy was not related to Parkinson's disease risk: the hazard ratio of Parkinson's disease comparing participants who reported any appendectomy with those who did not was 1.08 (95% confidence interval, 0.94-1.23). In women, appendectomy for appendicitis, but not incidental appendectomy, was associated with a modestly elevated risk of Parkinson's disease (hazard ratio, 1.23 [95% confidence interval, 1.00-1.50]).

Conclusions: Overall, this study suggests limited to no association between appendectomy and Parkinson's disease risk. © 2018 International Parkinson and Movement Disorder Society.

Keywords: Parkinson's; appendectomy; epidemiology; gut-brain axis.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Aged
  • Appendectomy / statistics & numerical data*
  • Cohort Studies
  • Female
  • Humans
  • Incidence
  • Male
  • Middle Aged
  • Parkinson Disease / epidemiology*
  • Proportional Hazards Models
  • Risk Factors
  • Self Report
  • Sex Characteristics*